Shirye-shiryen Bisphosphonate

Hoto na musamman na kwayoyi da ke hana lalata kasusuwa da halakarta ta amfani da osteoclasts yana amfani dasu a maganin osteoporosis a cikin mata. Bisphosphonate ko shirye-shiryen dysphosphonate sunadaran hade ne wadanda suke da tsarin kama da irin abubuwan da ake amfani da su na pyrophosphates zuwa resorption. A yau an dauke su ne kawai magunguna don osteoporosis tare da tabbatar da inganci.

Sunan sunayen shirye-shiryen bisphosphonate

Irin nau'in magani da aka yi la'akari da shi an ƙididdiga zuwa 2 manyan kungiyoyi - kwayoyi dauke da nitrogen da kwayoyi ba tare da shi ba.

Na farko iri-iri ya hada da:

1. Alendronic acid. Mai ƙarfi yana motsa sabunta tsarin da kuma samuwar tsarin tarihin kasusuwa, yana tsara tsarin musayarwa da sake koma baya. Yawancin lokaci ana ba da umurni ne ga magungunan daji da kuma musabausal osteoporosis, m hypercalcemia da deforming osteitis, don hana fractures;
2. Zolendronate ko zoledronic acid. Ƙarfafa aikin aikin osteoclasts, amma ba zai shafar tsarin tafiyar da kasusuwan kashi ba, kayan aikin injiniya da kuma samfurin halitta;
3. Clodronic acid (Clodron, Bonefos). Rage hadarin kamuwa da kasusuwa, yana haifar da sakamako mai cutarwa. An yi amfani dashi a gwajin gwaji, yana lalatar da macrophages pathological;
4. Bondronate (ibadronic acid). An tsara musamman domin kula da mata, musamman ma a cikin lokacin jima'i. Har ila yau, ana amfani dashi a lokacin maye gurbin hormonal.

Bezazotistye bisphosphonates za a iya dauka tare da metastases a cikin kashi, siffofin mai tsanani na m ciwace-ciwacen daji, hypercalcemia. A wannan yanayin, zaɓin daidai shine daidai sashi, wanda likita ya ƙidaya. In ba haka ba, musamman tare da overdose, matsaloli na iya faruwa.

Jerin jerin bishosphonate ba tare da nitrogen ba:

1. Tiludronate. Ƙara yawan ƙwayar nama, don haka an wajabta shi a gaban lalacewar da fractures;
2. Xidiphon, Pleistat ko sodium etidronate. An yi amfani dashi a cikin hadaddun maganin cutar Paget, cututtuka na halittu, hypercalcemia, mai tsanani osteoporosis;
3. Ibandronate sodium. Yana taimakawa sosai tare da maganin hormonal don maye gurbin magani a cikin lokacin post-menopausal;
4. Clodronate. Hana hana lalata kullun lu'ulu'u, da ci gaban osteolysis. An umurci miyagun ƙwayoyi don mummunan ciwon sukari, leukemias, lymphomas, mastastases masu yawa.

Umarni don bisphosphonates

Ana shigar da maganin magunguna da aka bayyana a sama kamar yadda shawarwarin likita suka kasance 1 lokaci a kowace rana.

Bisphosphonates suna da kyau sosai mai narkewa, don haka suna buƙatar wankewa tare da ruwa mai tsabta mai tsabta a dakin da zafin jiki mafi kyau.

Yana da kyawawa don tsayar da hutu tsakanin shigarwa abinci da bisphosphonate kwayoyi. Dole a dauki kwamfutar hannu 1,500 kafin cin abinci a ciki mai ciki - ba a baya ba kafin minti 60 bayan cin abinci.

Ɗaya daga cikin siffofin marasa kyau na wannan rukuni na kwayoyi shine ikon su na wulakanta mucosa na esophagus, don haifar da samuwar ƙananan ƙwayoyin cuta a kan farfajiya. Sabili da haka, bayan shan bisphosphonates ba za ku iya zuwa gadon kwanciyar hankali ba, yana da mahimmanci na minti 90 (m) don zama a cikin matsayi na gaskiya, za ku iya zama, amma ya fi kyau tafiya a ƙafa ko kawai yin aikin gida. Wannan zai hana irin wannan illa a matsayin ƙwannafin ƙwayar ƙwayar ƙwayar ƙwayar zuciya, da sake juyewar reflux da haɗin kai.